Ophthalmic Epidemiology Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, No. 23, Paidarfard St., Pasdaran Ave., Tehran, Iran.
Ocular Tissue Engineering Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, No 23, Paydar fard st, Pasdaran ave, Tehran, Iran.
Sci Rep. 2023 Jan 19;13(1):1074. doi: 10.1038/s41598-022-26349-x.
Investigating secular trends of ocular cancer registration in Iran. After acquiring Iranian national population-based cancer registry data, trends of age-standardised incidence rates (ASIR) of ocular cancers and annual percent changes (APC) between 2004 and 2016 were analysed in age groups, gender, topography and morphology types with joinpoint regression analysis. Age, period, and cohort effects on incidence rates were estimated by age-period-cohort model. Geographic distribution of ASIR was assessed using GIS. Overall ASIR of ocular cancers was 16.04/100,000 (95% CI 15.77-16.32). Joinpoint regression analysis showed a significant increase of ASIR between 2004 and 2009 for males (APC = 5.5, 95% CI 0.9-10.2), ages over 50 years (APC = 5.2, 1.2-9.4), skin/canthus/adnexal cancers (APC = 4.2, 0.8-7.7), and carcinomas/adenocarcinomas (APC = 4.3, 0.6-8.1); however, between 2009 and 2016 a declining trend was observed in all investigated variables. ASIR of retinoblastoma was significantly increased (averaged APC = 20.7, 9-33.7) between 2004 and 2016. age-period-cohort analyses showed that incidence rates of ocular cancers significantly increased with aging, time periods, and birth cohort effects (p < 0.001). ASIR varied from 6.7/100,000 to 21.7/100,000 in Iran. Excepting retinoblastoma, all ocular cancer incidence trends were downward over a 13-year period; however, it was increasing between 2004 and 2009 cancer. ASIR was significant aging in Iran.
研究伊朗眼部癌症登记的长期趋势。在获得伊朗全国人群癌症登记数据后，采用 Joinpoint 回归分析，分析了 2004 年至 2016 年各年龄段、性别、部位和形态类型的年龄标准化发病率（ASIR）趋势和年变化百分比（APC）。采用年龄-时期-队列模型估计发病率的年龄、时期和队列效应。使用 GIS 评估 ASIR 的地理分布。眼部癌症的总体 ASIR 为 16.04/100,000（95%CI 15.77-16.32）。Joinpoint 回归分析显示，2004 年至 2009 年男性（APC=5.5，95%CI 0.9-10.2）、50 岁以上人群（APC=5.2，1.2-9.4）、皮肤/结膜/附属器癌（APC=4.2，0.8-7.7）和癌/腺癌（APC=4.3，0.6-8.1）的 ASIR 呈显著上升趋势；然而，2009 年至 2016 年，所有调查变量均呈下降趋势。2004 年至 2016 年，视网膜母细胞瘤的 ASIR 显著增加（平均 APC=20.7，9-33.7）。年龄-时期-队列分析表明，眼部癌症的发病率随年龄、时期和出生队列效应的增加而显著增加（p<0.001）。伊朗的 ASIR 从 6.7/100,000 到 21.7/100,000 不等。除视网膜母细胞瘤外，所有眼部癌症的发病趋势在 13 年内均呈下降趋势；然而，2004 年至 2009 年癌症发病率呈上升趋势。伊朗的 ASIR 呈显著老龄化趋势。
