Buckwalter Joseph A, Martin James A, Brown Thomas D
University of Iowa, Department of Orthopaedics and Rehabilitation, Iowa City, IA 52242, USA.
Biorheology. 2006;43(3,4):603-9.
Osteoarthritis, the clinical syndrome of joint pain and dysfunction due to joint degeneration, is among the most frequent and symptomatic medical problems for middle aged and older people, and it is the most common cause of long term disability in most populations of people over 65. Currently there are no effective methods of preventing or curing osteoarthritis. Post-traumatic OA, the joint degeneration, pain and dysfunction that develop following joint injury, is the form of OA that is most directly related to elevated articular surface contact stress. However, mechanical stress that exceeds the tolerance of the articular surface can cause or accelerate the progression of joint degeneration in all individuals and in all synovial joints. In some patients, decreasing mechanical forces on degenerated joint surfaces stimulates formation of a new biologic articular surface. The advances in understanding of the effects of mechanical forces on chondrocytes and cartilage presented and discussed at the 4th Symposium on Mechanobiology: Cartilage and Chondrocyte will help in the efforts to develop new methods of preventing and treating osteoarthritis.
骨关节炎是由于关节退变导致关节疼痛和功能障碍的临床综合征，是中老年人最常见且有症状的医学问题之一，也是65岁以上大多数人群长期残疾的最常见原因。目前尚无预防或治愈骨关节炎的有效方法。创伤后骨关节炎是关节损伤后发生的关节退变、疼痛和功能障碍，是与关节表面接触应力升高最直接相关的骨关节炎形式。然而，超过关节表面耐受能力的机械应力可导致或加速所有个体和所有滑膜关节的关节退变进程。在一些患者中，降低退变关节表面的机械力可刺激新的生物关节表面形成。在第四届力学生物学研讨会：软骨与软骨细胞上展示和讨论的关于机械力对软骨细胞和软骨影响的研究进展，将有助于开发预防和治疗骨关节炎的新方法。
