Doronina Victoria A, Brown Jeremy D
Mol Biol (Mosk). 2006 Jul-Aug;40(4):731-41.
Regulation of protein synthesis at translation termination is a relatively under-explored, but rapidly expanding field. Recent advances in elucidating the mechanism of translation termination are helping to understand non-canonical events associated with translation termination. These "recoding" events include read-through of stop-codons, insertion of unusual amino acids such as selenocysteine and production of several polypeptides from one open reading frame. This review summarises data on termination-dependent recoding events, and proposes that there are two types of stop codon-associated sequences optimized to perform different functions: termination of translation per se or alternative elongation events.
翻译终止时蛋白质合成的调控是一个相对未被充分探索但正在迅速发展的领域。阐明翻译终止机制的最新进展有助于理解与翻译终止相关的非规范事件。这些“重新编码”事件包括终止密码子的通读、不寻常氨基酸（如硒代半胱氨酸）的插入以及从一个开放阅读框产生多种多肽。本综述总结了与终止相关的重新编码事件的数据，并提出存在两种与终止密码子相关的序列，它们经过优化以执行不同的功能：翻译本身的终止或替代延伸事件。
