Tauzin L, Risso F, Buffat C, Serra G, Simeoni U
Université de la Méditerranée, Faculté de Médecine, Marseille, France.
Pediatr Med Chir. 2005 Sep-Oct;27(5):18-23.
Several studies suggest that adverse events during foetal life can program cardiovascular diseases in adulthood. Barker et al. identified a relationship between low birth weight and an increased risk of arterial hypertension, carotid arteriosclerosis, and mortality by coronary heart disease or stroke in adulthood. These findings led to the "foetal origins" hypothesis, which is that cardiovascular disease originates in the adaptations to an adverse intrauterine environment. Such adaptations may permanently alter the cardiovascular structure and physiology through the process of programming. Several factors, such as impaired foetal growth, premature birth or postnatal growth of low birth weight infants may be involved, but to which extent is still unclear.
多项研究表明，胎儿期的不良事件可能会导致成年后患心血管疾病。巴克等人发现，低出生体重与成年后患动脉高血压、颈动脉粥样硬化以及因冠心病或中风导致的死亡风险增加之间存在关联。这些发现引发了“胎儿起源”假说，即心血管疾病起源于对不良子宫内环境的适应。这种适应可能会通过编程过程永久性地改变心血管结构和生理功能。可能涉及多个因素，如胎儿生长受限、早产或低出生体重婴儿的出生后生长情况，但具体程度尚不清楚。
