Pirzada Yasmin, Khuder Sadik, Donabedian Haig
College of Medicine, University of Toledo, Department of Internal Medicine, 3120 Glendale Ave, Toledo, OH 43614, USA.
AIDS Res Ther. 2006 Aug 17;3:20. doi: 10.1186/1742-6405-3-20.
The extent of immunosuppression and the probability of developing an AIDS-related complication in HIV-infected people is usually measured by the absolute number of CD4 positive T-cells. The percentage of CD4 positive cells is a more easily measured and less variable number. We analyzed sequential CD4 and CD8 numbers, percentages and ratios in 218 of our HIV infected patients to determine the most reliable predictor of an AIDS-related event.
The CD4 percentage was an unsurpassed predictor of the occurrence of AIDS-related events when all subsets of patients are considered. The CD4 absolute count was the next most reliable, followed by the ratio of CD4/CD8 percentages. The value of CD4 percentage over the CD4 absolute count was seen even after the introduction of highly effective HIV therapy.
The CD4 percentage is unsurpassed as a parameter for predicting the onset of HIV-related diseases. The extra time and expense of measuring the CD4 absolute count may be unnecessary.
HIV感染者的免疫抑制程度以及发生艾滋病相关并发症的可能性通常通过CD4阳性T细胞的绝对数量来衡量。CD4阳性细胞的百分比是一个更容易测量且变异性较小的数值。我们分析了218例HIV感染患者的连续CD4和CD8数量、百分比及比值，以确定艾滋病相关事件的最可靠预测指标。
当考虑所有患者亚组时，CD4百分比是艾滋病相关事件发生的无与伦比的预测指标。CD4绝对计数是其次最可靠的指标，其次是CD4/CD8百分比比值。即使在引入高效抗HIV治疗后，CD4百分比相对于CD4绝对计数的价值依然可见。
CD4百分比作为预测HIV相关疾病发病的参数是无与伦比的。测量CD4绝对计数所额外花费的时间和费用可能是不必要的。
