类风湿关节炎中的p38丝裂原活化蛋白激酶（MAPK）
p38 mitogen-activated protein kinase (MAPK) in rheumatoid arthritis.
作者信息
Westra J, Limburg P C
机构信息
Department of Rheumatology, University Medical Center Groningen, P.O. Box 30001, 9700 RB Groningen, The Netherlands.
出版信息
Mini Rev Med Chem. 2006 Aug;6(8):867-74. doi: 10.2174/138955706777934982.
PMID:16918493
Abstract
The importance of p38 MAPK inhibitors as new drug for rheumatoid arthritis is reflected by the large number of compounds that has been developed over the last years. In this review new insights such as non-stressful activation of p38 MAPK, and the role of p38 MAPK in regulation of NF-kappaB recruitment are also discussed.
摘要
在过去几年中已开发出大量化合物，这反映了p38丝裂原活化蛋白激酶（MAPK）抑制剂作为类风湿性关节炎新药的重要性。在这篇综述中，还讨论了一些新的见解，如p38 MAPK的非应激性激活以及p38 MAPK在调节核因子κB（NF-κB）募集方面的作用。
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