Bazanova E A, Gnezditskaia E V, Borodiiuk N A, Liampert I M
Zh Mikrobiol Epidemiol Immunobiol. 1990 Jan(1):80-4.
Antibodies to group A streptococcal polysaccharide (A-PS) have been shown to appear within three weeks after the injection of group A streptococcus culture, heat-killed and treated with pepsin (A-STP), in the blood of not only BALB/c mice, but also CBA mice. As revealed in this study, in BALB/c mice antibodies are mainly active against the group-specific antigenic determinant (AD) of A-PS and in CBA mice, against the rhamnose AD of A-PS, common for streptococci of different groups. This study has revealed that the appearance of antibodies to the rhamnose AD of A-PS in the blood of CBA mice inhibits antigen-specific cytotoxicity, appearing with the development of delayed hypersensitivity to BCG antigens. This effect is not linked with the immunization of the animals with high doses of streptococci. Experiments have shown that the in vitro transfer of the inhibition of antigen-specific cytotoxicity to lymph node cells of normal BCG-sensitized animals may be carried out with lymph node cells of CBA mice, immunized with A-STP and having antibodies to the rhamnose AD of A-PS, but not with the serum containing these antibodies. The mechanisms of this effect are discussed.
已证明，注射经胃蛋白酶处理的热灭活A组链球菌培养物（A-STP）后三周内，不仅BALB/c小鼠，而且CBA小鼠的血液中都会出现抗A组链球菌多糖（A-PS）的抗体。如本研究所示，在BALB/c小鼠中，抗体主要针对A-PS的群特异性抗原决定簇（AD），而在CBA小鼠中，抗体针对A-PS的鼠李糖AD，这是不同群链球菌共有的。本研究表明，CBA小鼠血液中出现的抗A-PS鼠李糖AD抗体可抑制抗原特异性细胞毒性，这种细胞毒性随着对卡介苗抗原迟发型超敏反应的发展而出现。这种效应与用高剂量链球菌免疫动物无关。实验表明，用A-STP免疫并具有抗A-PS鼠李糖AD抗体的CBA小鼠的淋巴结细胞可在体外将抗原特异性细胞毒性抑制作用转移至正常卡介苗致敏动物的淋巴结细胞，但含有这些抗体的血清则不能。本文讨论了这种效应的机制。
