Bazanova E A, Gnezditskaia E V, Liampert I M, Borodiiuk N A, Pyt'eva E Iu
Zh Mikrobiol Epidemiol Immunobiol. 1990 Aug(8):99-103.
The data obtained for the first time in our studies indicate that the production of antibodies to group A streptococcal polysaccharide (A-PS), one of the cross-reacting streptococcal antigens, may suppress delayed hypersensitivity (DH) to microbial antigens. The existence of sharply pronounced correlation between the suppression of DH and the presence of antibodies to the rhamnose area of A-PS in the blood of BALB/c mice immunized with the pepsin-treated culture of group A streptococci has been shown. The suppression of DH is absent in the immunized animals of the same group whose blood contains antibodies to the determinant, specific for A-PS. As revealed in this study, the effect of the suppression of antigen-specific cytotoxicity linked with DH to BCG antigens can be reproduced by mixing lymph node cells taken from these two groups of the animals. The data thus obtained are possibly linked with the activation of nonspecific T suppressors in the production of antibodies to the rhamnose determinants of A-PS in the animals immunized with streptococci. The mechanism of the newly discovered phenomenon is discussed.
我们研究首次获得的数据表明，针对交叉反应性链球菌抗原之一的A组链球菌多糖（A-PS）产生的抗体可能会抑制对微生物抗原的迟发型超敏反应（DH）。在用胃蛋白酶处理的A组链球菌培养物免疫的BALB/c小鼠血液中，已显示出DH抑制与A-PS鼠李糖区域抗体的存在之间存在明显的相关性。同一组免疫动物的血液中含有针对A-PS特异性决定簇的抗体，这些动物不存在DH抑制现象。如本研究所示，通过混合取自这两组动物的淋巴结细胞，可以重现与对卡介苗抗原的DH相关的抗原特异性细胞毒性抑制作用。由此获得的数据可能与在用链球菌免疫的动物中，针对A-PS鼠李糖决定簇产生抗体时非特异性T抑制细胞的激活有关。本文讨论了这一新发现现象的机制。
