Okulicz W C, Savasta A M, Hoberg L M, Longcope C
University of Massachusetts Medical School, Worcester 01655.
Fertil Steril. 1990 May;53(5):913-20. doi: 10.1016/s0015-0282(16)53531-6.
On day 9 of an artificial menstrual cycle (28 day) in the rhesus monkey, endometrial epithelia and stroma and myometrial smooth muscle cells showed positive immunoreactivity for estradiol (E2) and progesterone (P) receptor. On day 23 a reduction of staining for E2 and P receptor was observed for epithelial cells in endometrial zones I, II, and III with a pronounced loss of E2 receptor staining in stromal cells. Glandular epithelial cells in zone IV retained strong positive staining for both E2 and P receptor. Cytosolic and occupied nuclear E2 receptor analyzed biochemically were significantly reduced on day 23. These data suggest that P induces a zonal-dependent distribution of immunoreactive E2 and P receptor and that epithelial cells of zone IV are distinguished by the combined presence of strong immunoreactive staining for both receptors.
在恒河猴人工月经周期（28天）的第9天，子宫内膜上皮、基质以及子宫肌层平滑肌细胞对雌二醇（E2）和孕酮（P）受体呈阳性免疫反应。在第23天，观察到子宫内膜I区、II区和III区的上皮细胞中E2和P受体染色减少，基质细胞中E2受体染色明显丧失。IV区的腺上皮细胞对E2和P受体均保持强阳性染色。生化分析显示，第23天细胞溶质和核内结合的E2受体显著减少。这些数据表明，P诱导了免疫反应性E2和P受体的区域依赖性分布，并且IV区的上皮细胞以两种受体均有强免疫反应性染色为特征。
