Koike Haruki, Watanabe Hirohisa, Inukai Akira, Iijima Masahiro, Mori Keiko, Hattori Naoki, Sobue Gen
Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.
J Neurol Sci. 2006 Nov 15;249(2):175-9. doi: 10.1016/j.jns.2006.06.016. Epub 2006 Aug 22.
Tenderness in the limb muscles has been reported anecdotally in patients with beriberi neuropathy, but clinical effects of thiamine deficiency on skeletal muscle have received little attention.
To describe a patient with thiamine deficiency who manifested myopathic symptoms and responded well to thiamine supplementation.
A 26-year-old woman with neuropathy and heart failure associated with thiamine deficiency also complained of myalgia and weakness, most troublesome in the proximal portions of the limbs.
Serum creatine kinase, myoglobin, and aldolase concentrations were abnormally elevated. Magnetic resonance imaging of lower limb muscles demonstrated areas of high signal intensity in T2-weighted images and showed Gd-DTPA enhancement. A biopsy specimen from the quadriceps muscle showed myopathic changes without neurogenic changes. Abnormalities improved well with thiamine administration.
Myopathy may occur in patients with thiamine deficiency.
有报道称，脚气病性神经病患者的肢体肌肉会出现压痛，但硫胺素缺乏对骨骼肌的临床影响却很少受到关注。
描述一名表现出肌病症状且补充硫胺素后反应良好的硫胺素缺乏患者。
一名26岁女性，患有与硫胺素缺乏相关的神经病和心力衰竭，还主诉肌痛和肌无力，四肢近端最为严重。
血清肌酸激酶、肌红蛋白和醛缩酶浓度异常升高。下肢肌肉的磁共振成像显示，T2加权图像上有高信号强度区域，并显示钆喷酸葡胺增强。股四头肌活检标本显示有肌病改变，无神经源性改变。补充硫胺素后，异常情况得到明显改善。
硫胺素缺乏患者可能会发生肌病。
