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丝裂原活化蛋白激酶Hog1对酿酒酵母中对亚砷酸盐的应答至关重要。

Mitogen-activated protein kinase Hog1 is essential for the response to arsenite in Saccharomyces cerevisiae.

作者信息

Sotelo Jael, Rodríguez-Gabriel Miguel A

机构信息

Departamento de Microbiología II. Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain.

出版信息

Eukaryot Cell. 2006 Oct;5(10):1826-30. doi: 10.1128/EC.00225-06. Epub 2006 Aug 18.

DOI:10.1128/EC.00225-06
PMID:16920868
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1595349/
Abstract

Here we describe, for the first time, that budding yeast mitogen-activated protein kinase Hog1 and its upstream activators Pbs2 and Ssk1 are essential for the response to arsenite. Hog1 is rapidly phosphorylated in response to arsenite and triggers a transcriptional response that involves the upregulation of genes essential for arsenite detoxification.

摘要

在此，我们首次描述了出芽酵母丝裂原活化蛋白激酶Hog1及其上游激活因子Pbs2和Ssk1对于亚砷酸盐应答至关重要。Hog1在亚砷酸盐刺激下迅速磷酸化，并引发转录应答，其中涉及对亚砷酸盐解毒至关重要的基因上调。

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本文引用的文献

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A downshift in temperature activates the high osmolarity glycerol (HOG) pathway, which determines freeze tolerance in Saccharomyces cerevisiae.温度下降会激活高渗甘油（HOG）途径，该途径决定了酿酒酵母的耐冻性。
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Distinct signaling pathways respond to arsenite and reactive oxygen species in Schizosaccharomyces pombe.不同的信号通路对粟酒裂殖酵母中的亚砷酸盐和活性氧作出反应。
Eukaryot Cell. 2005 Aug;4(8):1396-402. doi: 10.1128/EC.4.8.1396-1402.2005.
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Kinetic analysis of YPD1-dependent phosphotransfer reactions in the yeast osmoregulatory phosphorelay system.酵母渗透调节磷酸化信号转导系统中YPD1依赖性磷酸转移反应的动力学分析
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Oxidative stress activates FUS1 and RLM1 transcription in the yeast Saccharomyces cerevisiae in an oxidant-dependent Manner.氧化应激以氧化剂依赖的方式激活酿酒酵母中的FUS1和RLM1转录。
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Yap8p activation in Saccharomyces cerevisiae under arsenic conditions.酿酒酵母在砷环境下Yap8p的激活
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