Hardy Richard R
Division of Basic Sciences, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
J Immunol. 2006 Sep 1;177(5):2749-54. doi: 10.4049/jimmunol.177.5.2749.
CD5+ B cells have attracted considerable interest because of their association with self-reactivity, autoimmunity, and leukemia. In mice, CD5+ B cells are readily generated from fetal/neonatal precursors, but inefficiently from precursors in adult. One model proposed to explain this difference is that their production occurs through a distinctive developmental process, termed B-1, that enriches pre-B cells with novel germline VDJs and that requires positive selection of newly formed B cells by self-Ag. In contrast, follicular B cells are generated throughout adult life in a developmental process termed B-2, selecting VDJs that pair well with surrogate L chain, and whose maturation appears relatively independent of antigenic selection. In the present study, I focus on processes that shape the repertoire of mouse CD5+ B cells, describing the differences between B-1 and B-2 development, and propose a model encompassing both in the generation of functional B cell subpopulations.
CD5⁺ B细胞因其与自身反应性、自身免疫和白血病的关联而备受关注。在小鼠中，CD5⁺ B细胞很容易从胎儿/新生儿前体细胞产生，但从成年前体细胞产生的效率较低。为解释这种差异而提出的一种模型是，它们的产生通过一个独特的发育过程，称为B-1，该过程使前B细胞富含新的种系VDJ，并且需要通过自身抗原对新形成的B细胞进行阳性选择。相比之下，滤泡B细胞在整个成年期通过一个称为B-2的发育过程产生，选择与替代轻链配对良好的VDJ，并且其成熟似乎相对独立于抗原选择。在本研究中，我关注塑造小鼠CD5⁺ B细胞库的过程，描述B-1和B-2发育之间的差异，并提出一个涵盖两者在功能性B细胞亚群产生过程中的模型。
