Pers J O, Jamin C, Predine-Hug F, Lydyard P, Youinou P
Division of Dentistry, Brest University Medical School Hospital, Brest, France.
Int J Mol Med. 1999 Mar;3(3):239-45. doi: 10.3892/ijmm.3.3.239.
The CD5(+) B cell population is prominent in early life and produce low avidity and, thereby, polyreactive antibodies. CD5(+) B cells are receptive to cytokines and interleukin-10 seems to be influential in the regulation of some of these CD5(+) B cells. The question of whether CD5 is a marker of activation or a molecule specific for a B cell lineage remains unresolved because evidence in support or against a separate lineage are still a matter for debate. However, we suggest the possibility of different kind of CD5(+) B cells. Indeed, activated CD5(+) B cells do proliferate, following CD5 engagement, while resting CD5(+) B cells do not. Moreover, three ligands for CD5 have, thus far, been identified but their functional effects are yet unknown. CD5(+) B cells probably play a role in setting up the idiotype network, antigen presentation and tolerance induction. B cells of most of the chronic lymphoid leukemias express CD5 molecules and, surprisingly, these cells may be expanded in non-organ-specific autoimmune diseases, such as rheumatoid arthritis or primary Sjögren's syndrome. CD5(+) B cells seems to be involved in the autoantibody production (this does not necessarily imply that pathogenic autoantibodies are produced by CD5(+) B cells) in autoimmune disease and particularly susceptible to transformation in lymphoproliferative disorders. Thus, this B cell population appears to play a key role at the crossroad of the non-organ-specific autoimmune diseases and B lymphoproliferative disorders.
CD5(+) B细胞群体在生命早期较为突出，产生低亲和力、因而具有多反应性的抗体。CD5(+) B细胞对细胞因子敏感，白细胞介素-10似乎在调控其中一些CD5(+) B细胞方面具有影响力。CD5是激活标志物还是B细胞谱系特异性分子的问题仍未解决，因为支持或反对独立谱系的证据仍存在争议。然而，我们提出存在不同类型CD5(+) B细胞的可能性。事实上，活化的CD5(+) B细胞在CD5参与后确实会增殖，而静止的CD5(+) B细胞则不会。此外，迄今已鉴定出三种CD5配体，但其功能作用尚不清楚。CD5(+) B细胞可能在建立独特型网络、抗原呈递和诱导耐受中发挥作用。大多数慢性淋巴细胞白血病的B细胞表达CD5分子，令人惊讶的是，这些细胞可能在非器官特异性自身免疫性疾病（如类风湿关节炎或原发性干燥综合征）中扩增。CD5(+) B细胞似乎参与自身免疫性疾病中的自身抗体产生（这不一定意味着致病性自身抗体由CD5(+) B细胞产生），并且在淋巴增殖性疾病中特别容易发生转化。因此，这群B细胞似乎在非器官特异性自身免疫性疾病和B淋巴增殖性疾病的交叉点上发挥关键作用。
