Eddie L W, Martinez F, Healy D L, Sutton B, Bell R J, Tregear G W
Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia.
Br J Obstet Gynaecol. 1990 Mar;97(3):215-20. doi: 10.1111/j.1471-0528.1990.tb01784.x.
To identify the time when relaxin can first be detected in peripheral sera after in-vitro fertilization (IVF) and embryo transfer, blood samples were collected from 20 women up to 14 days after oocyte retrieval. Sixteen women did not become pregnant and in eight of them relaxin (but not beta-human chorionic gonadotrophin, beta-hCG) was measurable for the first time at days 6 to 12. Concentrations of other hormones measured were also different in these eight women compared with the remaining eight non-pregnant women; their serum concentrations of 17 alpha-OH progesterone, progesterone and oestradiol were higher but concentrations of luteinizing hormone and follicle-stimulating hormone were lower. Three women became pregnant; relaxin and beta-hCG were first detected on the same day (10 to 12). The remaining woman had increased beta-hCG levels but did not develop a clinical pregnancy. Measurement of serum relaxin during IVF cycles may allow assessment of corpora luteal function before its identification by levels of steroid hormones.
为了确定体外受精（IVF）和胚胎移植后外周血清中首次检测到松弛素的时间，在取卵后长达14天的时间里，从20名女性身上采集了血样。16名女性未怀孕，其中8名女性在第6至12天首次检测到松弛素（但未检测到β-人绒毛膜促性腺激素，β-hCG）。与其余8名未怀孕女性相比，这8名女性所检测的其他激素浓度也有所不同；她们血清中的17α-羟孕酮、孕酮和雌二醇浓度较高，但促黄体生成素和促卵泡激素浓度较低。3名女性怀孕；松弛素和β-hCG在同一天首次检测到（第10至12天）。其余一名女性β-hCG水平升高，但未临床妊娠。在IVF周期中检测血清松弛素，可能在通过甾体激素水平确定黄体功能之前对其进行评估。
