Kristiansson P, Svärdsudd K, von Schoultz B, Wramsby H
Department of Obstetrics & Gynecology, Karolinska Hospital, Stockholm, Sweden.
Hum Reprod. 1996 Sep;11(9):2036-40. doi: 10.1093/oxfordjournals.humrep.a019539.
In order to analyse the relationship between the ovarian response to stimulation in in-vitro fertilization (IVF) treatment cycles and relaxin concentrations during subsequent pregnancies, 31 healthy women pregnant after IVF treatment were studied prospectively. The maximum number of follicles observed from day -4 to day -2 in relation to ovum retrieval and the number of oocytes recovered were recorded. In addition, blood samples were drawn in the follicular phase, the luteal phase, early pregnancy and at gestational weeks 12, 16, 20, 27 and 35 to assess oestradiol, progesterone, human chorionic gonadotrophin and relaxin. The maximum numbers (mean +/- SEM) of follicles observed and oocytes recovered were 9.0 +/- 0.6 and 6.1 +/- 0.5 respectively. The supraphysiological mean relaxin values were strongly correlated to the maximum number of follicles observed (r = 0.72, P < 0.0001) and the number of oocytes recovered (r = 0.64, P < 0.0001), indicating that the source of increased relaxin production during IVF pregnancy might be the ovary. These results are supported by experimental data. In the present study, the occurrence of multiple pregnancy was not associated with higher relaxin concentrations, which is further support for the hypothesis that the ovary is the main source of serum relaxin.
为了分析体外受精（IVF）治疗周期中卵巢对刺激的反应与后续妊娠期间松弛素浓度之间的关系，对31名IVF治疗后怀孕的健康女性进行了前瞻性研究。记录了从取卵前第4天到第2天观察到的卵泡最大数量以及回收的卵母细胞数量。此外，在卵泡期、黄体期、孕早期以及妊娠第12、16、20、27和35周采集血样，以评估雌二醇、孕酮、人绒毛膜促性腺激素和松弛素。观察到的卵泡最大数量（平均值±标准误）和回收的卵母细胞数量分别为9.0±0.6和6.1±0.5。超生理水平的平均松弛素值与观察到的卵泡最大数量（r = 0.72，P < 0.0001）和回收的卵母细胞数量（r = 0.64，P < 0.0001）密切相关，这表明IVF妊娠期间松弛素产生增加的来源可能是卵巢。这些结果得到了实验数据的支持。在本研究中，多胎妊娠的发生与较高的松弛素浓度无关，这进一步支持了卵巢是血清松弛素主要来源的假说。
