Escobar Andrés J Gutiérrez, Arenas Aylan Farid, Gómez-Marin Jorge Enrique
Grupo de Parasitología Molecular (GEPAMOL), Centro de Investigaciones Biomédicas, Facultad de Ciencias de la Salud, Universidad del Quindío, Armenia, Colombia.
In Silico Biol. 2006;6(4):347-50.
The serine-rich (SR) protein family is involved in the pre-mRNA splicing process and the DNA sequences of the corresponding genes are highly conserved in the metazoan organisms. The mammalian SR proteins consist of one or two characteristic RNA binding domains (RBD), containing the signature sequences RDAEDA and SWQDLKD and a RS (arginine/serine-rich) domain. We used the amino acid and nucleotide sequences deposited in GenBank and Swiss-Prot databases to perform a phylogenetic analysis using bioinformatics tools. The results of the phylogenetic trees suggest that this family has evolved by several gene duplication events as a result of a positive selection mechanism.
富含丝氨酸（SR）蛋白家族参与前体mRNA剪接过程，并且相应基因的DNA序列在后生动物中高度保守。哺乳动物SR蛋白由一个或两个特征性RNA结合结构域（RBD）组成，包含特征序列RDAEDA和SWQDLKD以及一个RS（富含精氨酸/丝氨酸）结构域。我们使用GenBank和Swiss-Prot数据库中存储的氨基酸和核苷酸序列，利用生物信息学工具进行了系统发育分析。系统发育树的结果表明，由于正选择机制，该家族通过几次基因复制事件进化而来。
