Marynen P, Devriendt K, Van den Berghe H, Cassiman J J
Center for Human Genetics, University of Leuven, Belgium.
FEBS Lett. 1990 Mar 26;262(2):349-52. doi: 10.1016/0014-5793(90)80226-9.
Genomic clones containing the exons coding for the bait domain of human pregnancy zone protein and alpha 2 macroglobulin were isolated and fragments containing the bait exons were sequenced. It is shown that the bait domains of both alpha 2 macroglobulin and pregnancy zone protein are encoded by two exons, with conserved exon/intron boundaries. A genetic polymorphism showing either a Met or a Val residue as the sixth amino acid of the pregnancy zone protein bait domain was detected with the rare Met allele showing a gene frequency of 0.065.
分离出了包含编码人妊娠区蛋白和α2巨球蛋白诱饵结构域的外显子的基因组克隆，并对含有诱饵外显子的片段进行了测序。结果表明，α2巨球蛋白和妊娠区蛋白的诱饵结构域均由两个外显子编码，外显子/内含子边界保守。检测到一种基因多态性，妊娠区蛋白诱饵结构域的第六个氨基酸为甲硫氨酸（Met）或缬氨酸（Val）残基，罕见的甲硫氨酸等位基因的基因频率为0.065。
