Valk W L, Wit H P, Albers F W J
Department of Otorhinolaryngology, University Medical Center Groningen, Groningen, The Netherlands.
Acta Otolaryngol. 2006 Oct;126(10):1030-5. doi: 10.1080/00016480600621722.
The changes in cochlear function during a destructive acute endolymphatic hydrops were relatively small. This might be consistent with the hypothesis that an endolymphatic hydrops is a marker of disordered inner ear homeostasis rather than the cause of the clinical symptoms of Ménière's disease.
Assessment of cochlear function during induction of a destructive acute endolymphatic hydrops.
During repetitive microinjections of 0.5 microl of artificial endolymph at a rate of 50 nl/s the 2f1-f2 and f2-f1 cochlear microphonics distortion products (CMDP) and 2f1-f2 distortion products otoacoustic emissions (DPOAE) were recorded in the guinea pig.
A 'catastrophe' occurred in the inner ear when 2.5-3.5 microl of artificial endolymph was injected. A rupture of Reissner's membrane was then found, most often in the apical turn of the cochlea. This rupture had only minor effects on the endocochlear potential, whereas it caused a marked decrease in 2f1-f2 DPOAE amplitude. The 2f1-f2 and f2-f1 CMDP amplitude increased during each injection prior to the rupture. After the rupture the f2-f1 CMDP amplitude decreased during each injection, possibly due to a shift of the cochlear transducer operating point position.
在破坏性急性内淋巴积水期间，耳蜗功能的变化相对较小。这可能与以下假设一致，即内淋巴积水是内耳内环境稳态紊乱的一个标志，而非梅尼埃病临床症状的病因。
评估破坏性急性内淋巴积水诱发过程中的耳蜗功能。
以50 nl/s的速率对豚鼠重复微量注射0.5微升人工内淋巴，同时记录2f1-f2和f2-f1耳蜗微音畸变产物（CMDP）以及2f1-f2畸变产物耳声发射（DPOAE）。
当注射2.5 - 3.5微升人工内淋巴时，内耳发生“灾难”。随后发现Reissner膜破裂，最常发生在耳蜗顶转。这种破裂对内耳电位影响较小，而导致2f1-f2 DPOAE幅度显著下降。在破裂前的每次注射过程中，2f1-f2和f2-f1 CMDP幅度增加。破裂后，每次注射时f2-f1 CMDP幅度下降，可能是由于耳蜗换能器工作点位置的改变。
