钙调神经磷酸酶促进白色念珠菌对角膜的感染，可作为靶点以增强氟康唑治疗效果。
Calcineurin promotes infection of the cornea by Candida albicans and can be targeted to enhance fluconazole therapy.
作者信息
Onyewu Chiatogu, Afshari Natalie A, Heitman Joseph
机构信息
Department of Ophthalmology, Wadsworth Bldg., Box 3802, Erwin Road, Duke University Eye Center, Durham, NC 27710, USA.
出版信息
Antimicrob Agents Chemother. 2006 Nov;50(11):3963-5. doi: 10.1128/AAC.00393-06. Epub 2006 Aug 21.
Abstract
In an established Candida albicans murine keratitis model, combination therapy with ophthalmic preparations of fluconazole and cyclosporine A (CsA) demonstrated in vivo drug synergy and effectively resolved wild-type C. albicans infection more rapidly than monotherapy with either drug. Calcineurin, the target of CsA, was also found to contribute to pathogenicity.
摘要
在已建立的白色念珠菌小鼠角膜炎模型中，氟康唑和环孢素A（CsA）的眼科制剂联合治疗显示出体内药物协同作用，并且比单用任何一种药物更迅速有效地解决了野生型白色念珠菌感染。CsA的靶标钙调神经磷酸酶也被发现与致病性有关。
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