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Calcineurin promotes infection of the cornea by Candida albicans and can be targeted to enhance fluconazole therapy.钙调神经磷酸酶促进白色念珠菌对角膜的感染，可作为靶点以增强氟康唑治疗效果。
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2
The calcineruin inhibitor cyclosporine a synergistically enhances the susceptibility of Candida albicans biofilms to fluconazole by multiple mechanisms.钙调神经磷酸酶抑制剂环孢素A通过多种机制协同增强白色念珠菌生物膜对氟康唑的敏感性。
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3
Ibuprofen potentiates the in vivo antifungal activity of fluconazole against Candida albicans murine infection.布洛芬增强氟康唑对白色念珠菌小鼠感染的体内抗真菌活性。
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Sequential therapy with caspofungin and fluconazole for Candida albicans infection.卡泊芬净与氟康唑序贯治疗白色念珠菌感染。
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Calcineurin A of Candida albicans: involvement in antifungal tolerance, cell morphogenesis and virulence.白色念珠菌的钙调神经磷酸酶A：参与抗真菌耐受性、细胞形态发生和毒力。
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Combined topical fluconazole and corticosteroid treatment for experimental Candida albicans keratomycosis.联合局部用氟康唑和皮质类固醇治疗实验性白色念珠菌性角膜真菌病。
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Calcineurin activity in Fonsecaea pedrosoi: tacrolimus and cyclosporine A inhibited conidia growth, filamentation and showed synergism with itraconazole.佩德罗霉样真菌中的钙调神经磷酸酶活性：他克莫司和环孢素A抑制分生孢子生长、丝状化，并与伊曲康唑表现出协同作用。
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Components of the calcium-calcineurin signaling pathway in fungal cells and their potential as antifungal targets.真菌细胞中钙-钙调神经磷酸酶信号通路的组成部分及其作为抗真菌靶点的潜力。
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Posaconazole exhibits in vitro and in vivo synergistic antifungal activity with caspofungin or FK506 against Candida albicans.泊沙康唑与卡泊芬净或 FK506 体外和体内联合抗白念珠菌均具有协同作用。
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Calcium-activated-calcineurin reduces the In vitro and In vivo sensitivity of fluconazole to Candida albicans via Rta2p.钙调神经磷酸酶激活钙调神经磷酸酶降低了白念珠菌对氟康唑的体外和体内敏感性，通过 Rta2p。
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Direct effects of non-antifungal agents used in cancer chemotherapy and organ transplantation on the development and virulence of Candida and Aspergillus species.癌症化疗和器官移植中使用的非抗真菌药物对念珠菌属和曲霉属物种的发育和毒力的直接影响。
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本文引用的文献

1
Role of calcineurin in stress resistance, morphogenesis, and virulence of a Candida albicans wild-type strain.钙调神经磷酸酶在白色念珠菌野生型菌株的应激抗性、形态发生及毒力中的作用
Infect Immun. 2006 Jul;74(7):4366-9. doi: 10.1128/IAI.00142-06.
2
The calcineurin target, Crz1, functions in azole tolerance but is not required for virulence of Candida albicans.钙调神经磷酸酶的靶点Crz1在唑类耐受性中发挥作用，但白色念珠菌的毒力并不需要它。
Infect Immun. 2004 Dec;72(12):7330-3. doi: 10.1128/IAI.72.12.7330-7333.2004.
3
Fungicidal activity of fluconazole against Candida albicans in a synthetic vagina-simulative medium.氟康唑在合成阴道模拟培养基中对白色念珠菌的杀菌活性。
Antimicrob Agents Chemother. 2004 Jan;48(1):161-7. doi: 10.1128/AAC.48.1.161-167.2004.
4
Fungal infections of the cornea.角膜真菌感染
Eye (Lond). 2003 Nov;17(8):852-62. doi: 10.1038/sj.eye.6700557.
5
Current perspectives on ophthalmic mycoses.眼部真菌病的当前观点
Clin Microbiol Rev. 2003 Oct;16(4):730-97. doi: 10.1128/CMR.16.4.730-797.2003.
6
Calcineurin is essential for virulence in Candida albicans.钙调神经磷酸酶对白色念珠菌的毒力至关重要。
Infect Immun. 2003 Sep;71(9):5344-54. doi: 10.1128/IAI.71.9.5344-5354.2003.
7
Calcineurin is essential for Candida albicans survival in serum and virulence.钙调神经磷酸酶对于白色念珠菌在血清中的存活及毒力至关重要。
Eukaryot Cell. 2003 Jun;2(3):422-30. doi: 10.1128/EC.2.3.422-430.2003.
8
Calcineurin A of Candida albicans: involvement in antifungal tolerance, cell morphogenesis and virulence.白色念珠菌的钙调神经磷酸酶A：参与抗真菌耐受性、细胞形态发生和毒力。
Mol Microbiol. 2003 May;48(4):959-76. doi: 10.1046/j.1365-2958.2003.03495.x.
9
Experimental keratomycosis in a mouse model.小鼠模型中的实验性角膜真菌病
Invest Ophthalmol Vis Sci. 2003 Jan;44(1):210-6. doi: 10.1167/iovs.02-0446.
10
Resistance mechanisms in clinical isolates of Candida albicans.白色念珠菌临床分离株中的耐药机制。
Antimicrob Agents Chemother. 2002 Jun;46(6):1704-13. doi: 10.1128/AAC.46.6.1704-1713.2002.

钙调神经磷酸酶促进白色念珠菌对角膜的感染，可作为靶点以增强氟康唑治疗效果。

Calcineurin promotes infection of the cornea by Candida albicans and can be targeted to enhance fluconazole therapy.

作者信息

Onyewu Chiatogu, Afshari Natalie A, Heitman Joseph

机构信息

Department of Ophthalmology, Wadsworth Bldg., Box 3802, Erwin Road, Duke University Eye Center, Durham, NC 27710, USA.

出版信息

Antimicrob Agents Chemother. 2006 Nov;50(11):3963-5. doi: 10.1128/AAC.00393-06. Epub 2006 Aug 21.

DOI:10.1128/AAC.00393-06
PMID:16923949
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1635197/
Abstract

In an established Candida albicans murine keratitis model, combination therapy with ophthalmic preparations of fluconazole and cyclosporine A (CsA) demonstrated in vivo drug synergy and effectively resolved wild-type C. albicans infection more rapidly than monotherapy with either drug. Calcineurin, the target of CsA, was also found to contribute to pathogenicity.

摘要

在已建立的白色念珠菌小鼠角膜炎模型中，氟康唑和环孢素A（CsA）的眼科制剂联合治疗显示出体内药物协同作用，并且比单用任何一种药物更迅速有效地解决了野生型白色念珠菌感染。CsA的靶标钙调神经磷酸酶也被发现与致病性有关。