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布洛芬增强氟康唑对白色念珠菌小鼠感染的体内抗真菌活性。

Ibuprofen potentiates the in vivo antifungal activity of fluconazole against Candida albicans murine infection.

作者信息

Costa-de-Oliveira Sofia, Miranda Isabel M, Silva-Dias Ana, Silva Ana P, Rodrigues Acácio G, Pina-Vaz Cidália

机构信息

Department of Microbiology, Faculty of Medicine, University of Porto, Porto, Portugal CINTESIS-Center for Health Technology and Services Research, Faculty of Medicine, University of Porto, Porto, Portugal

Department of Microbiology, Faculty of Medicine, University of Porto, Porto, Portugal CINTESIS-Center for Health Technology and Services Research, Faculty of Medicine, University of Porto, Porto, Portugal.

出版信息

Antimicrob Agents Chemother. 2015 Jul;59(7):4289-92. doi: 10.1128/AAC.05056-14. Epub 2015 Apr 6.

DOI:10.1128/AAC.05056-14
PMID:25845879
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4468673/
Abstract

Candida albicans is the most prevalent cause of fungemia worldwide. Its ability to develop resistance in patients receiving azole antifungal therapy is well documented. In a murine model of systemic infection, we show that ibuprofen potentiates fluconazole antifungal activity against a fluconazole-resistant strain, drastically reducing the fungal burden and morbidity. The therapeutic combination of fluconazole with ibuprofen may constitute a new approach for the management of antifungal therapeutics to reverse the resistance conferred by efflux pump overexpression.

摘要

白色念珠菌是全球范围内引起真菌血症最常见的病因。其在接受唑类抗真菌治疗的患者中产生耐药性的能力已有充分记录。在一个系统性感染的小鼠模型中，我们发现布洛芬可增强氟康唑对氟康唑耐药菌株的抗真菌活性，大幅降低真菌负荷和发病率。氟康唑与布洛芬的联合治疗可能构成一种新的抗真菌治疗方法，以逆转由外排泵过表达所赋予的耐药性。

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本文引用的文献

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Infect Immun. 2014 Feb;82(2):532-43. doi: 10.1128/IAI.01417-13. Epub 2013 Nov 11.
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Epidemiological changes with potential implication for antifungal prescription recommendations for fungaemia: data from a nationwide fungaemia surveillance programme.真菌血症的流行病学变化及其对抗真菌药物处方建议的潜在影响：一项全国性真菌血症监测计划的数据。
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Progress in antifungal susceptibility testing of Candida spp. by use of Clinical and Laboratory Standards Institute broth microdilution methods, 2010 to 2012.2010 至 2012 年，利用临床和实验室标准协会微量肉汤稀释法对抗真菌药敏试验中念珠菌属的研究进展。
J Clin Microbiol. 2012 Sep;50(9):2846-56. doi: 10.1128/JCM.00937-12. Epub 2012 Jun 27.
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Antifungal drug resistance: mechanisms, epidemiology, and consequences for treatment.抗真菌药物耐药性：机制、流行病学及对治疗的影响。
Am J Med. 2012 Jan;125(1 Suppl):S3-13. doi: 10.1016/j.amjmed.2011.11.001.
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Candida albicans dimorphism as a therapeutic target.白色念珠菌的二相性作为治疗靶点。
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6
In vitro synergisms obtained by amphotericin B and voriconazole associated with non-antifungal agents against Fusarium spp.两性霉素 B 和伏立康唑与非抗真菌药物联合应用对镰刀菌属的体外协同作用
Diagn Microbiol Infect Dis. 2011 Oct;71(2):126-30. doi: 10.1016/j.diagmicrobio.2011.05.007. Epub 2011 Aug 15.
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Organ-specific innate immune responses in a mouse model of invasive candidiasis.侵袭性念珠菌病小鼠模型中的器官特异性固有免疫反应。
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Requirement for ergosterol in V-ATPase function underlies antifungal activity of azole drugs.唑类抗真菌药物发挥抗真菌活性的基础是 V-ATPase 功能所需的麦角固醇。
PLoS Pathog. 2010 Jun 3;6(6):e1000939. doi: 10.1371/journal.ppat.1000939.
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Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection.白色念珠菌唑类耐药机制的遗传剖析及其在播散性感染小鼠模型中的验证。
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