布洛芬增强氟康唑对白色念珠菌小鼠感染的体内抗真菌活性。
Ibuprofen potentiates the in vivo antifungal activity of fluconazole against Candida albicans murine infection.
作者信息
Costa-de-Oliveira Sofia, Miranda Isabel M, Silva-Dias Ana, Silva Ana P, Rodrigues Acácio G, Pina-Vaz Cidália
机构信息
Department of Microbiology, Faculty of Medicine, University of Porto, Porto, Portugal CINTESIS-Center for Health Technology and Services Research, Faculty of Medicine, University of Porto, Porto, Portugal
Department of Microbiology, Faculty of Medicine, University of Porto, Porto, Portugal CINTESIS-Center for Health Technology and Services Research, Faculty of Medicine, University of Porto, Porto, Portugal.
出版信息
Antimicrob Agents Chemother. 2015 Jul;59(7):4289-92. doi: 10.1128/AAC.05056-14. Epub 2015 Apr 6.
Abstract
Candida albicans is the most prevalent cause of fungemia worldwide. Its ability to develop resistance in patients receiving azole antifungal therapy is well documented. In a murine model of systemic infection, we show that ibuprofen potentiates fluconazole antifungal activity against a fluconazole-resistant strain, drastically reducing the fungal burden and morbidity. The therapeutic combination of fluconazole with ibuprofen may constitute a new approach for the management of antifungal therapeutics to reverse the resistance conferred by efflux pump overexpression.
摘要
白色念珠菌是全球范围内引起真菌血症最常见的病因。其在接受唑类抗真菌治疗的患者中产生耐药性的能力已有充分记录。在一个系统性感染的小鼠模型中，我们发现布洛芬可增强氟康唑对氟康唑耐药菌株的抗真菌活性，大幅降低真菌负荷和发病率。氟康唑与布洛芬的联合治疗可能构成一种新的抗真菌治疗方法，以逆转由外排泵过表达所赋予的耐药性。
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