A case report of oxidative stress in a patient with anorexia nervosa.
作者信息
Tajiri Kazuto, Shimizu Yukihiro, Tsuneyama Koichi, Sugiyama Toshiro
机构信息
Third Department of Internal Medicine, Faculty of Medicine, University of Toyama, Toyama, Japan.
出版信息
Int J Eat Disord. 2006 Nov;39(7):616-8. doi: 10.1002/eat.20326.
OBJECTIVE
Liver injury is well known as a complication of anorexia nervosa (AN), and steatosis of the liver has been thought to be the main cause of the injury. However, the precise mechanism for the liver injury is still unclear.
METHOD AND RESULTS
We had a chance to examine the histological change of the liver with AN, and found that not only fat deposit but also peroxidated lipid products and irons were recognized in hepatocytes.
CONCLUSION
Our present case demonstrates that oxidative stresses in hepatocytes, which might be associated with iron deposition, could be involved in the pathogenesis of liver injury in patients with AN.
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