Direct N-acetyl enamine formation: lithium bromide mediated addition of methyllithium to nitriles.
作者信息
Savarin Cécile G, Boice Geneviève N, Murry Jerry A, Corley Edward, DiMichele Lisa, Hughes Dave
机构信息
Department of Process Research, Merck Research Laboratories, Merck & Company, P.O. Box 2000, Rahway, NJ 07065, USA.
出版信息
Org Lett. 2006 Aug 31;8(18):3903-6. doi: 10.1021/ol061318k.
PMID:16928034
Abstract
An improved protocol for N-acetyl enamine formation is disclosed which involves LiBr-mediated addition of MeLi to substituted nitriles. The resulting enamides are isolated in high yields and excellent purity which permits subsequent hydrogenation at very low catalyst loading.
摘要
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