DeBenedetto Mikkel V, Green Michael E, Wan Shuangyi, Park Jung-Hyun, Floreancig Paul E
Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
Org Lett. 2009 Feb 19;11(4):835-8. doi: 10.1021/ol802764j.
Alpha-branched amides are prepared by multicomponent reactions in which nitriles undergo hydrozirconation to form metalloimines that react with acyl chlorides. The resulting acylimines react with a variety of pi-nucleophiles in the presence of Lewis acids to form the desired amides.
α-支链酰胺是通过多组分反应制备的,在该反应中腈进行氢锆化反应形成金属亚胺,金属亚胺再与酰氯反应。生成的酰亚胺在路易斯酸存在下与多种π-亲核试剂反应,形成所需的酰胺。