高效抗逆转录病毒疗法引入前后，HIV感染者中与HIV感染相关的死亡率及死亡原因的变化：巴巴多斯1997 - 2005年所有HIV相关死亡病例分析

Changing HIV infection-related mortality rate and causes of death among persons with HIV infection before and after the introduction of highly active antiretroviral therapy: analysis of all HIV-related deaths in Barbados, 1997-2005.

作者信息

Kumar Alok, Kilaru Krishna R, Forde Sheila, Roach Timothy C

机构信息

School of Clinical Medicine & Research, University of the West Indies (Cave Hill Campus) and Queen Elizabeth Hospital, Barbados, West Indies.

出版信息

J Int Assoc Physicians AIDS Care (Chic). 2006 Sep;5(3):109-14. doi: 10.1177/1545109706288587.

DOI:10.1177/1545109706288587

PMID:16928879

Abstract

OBJECTIVES

To compare the trends in death rates and the causes of deaths before and after the introduction of highly active antiretroviral therapy.

METHODS

This is a retrospective study based on chart review of all HIV-related deaths between January 1997 and December 2005.

RESULTS

The HIV-specific death rate declined from 34.12 per 100,000 adult population during 1997-1999 to 17.21 per 100,000 adult population during 2003-2005 when highly active anti-retroviral therapy was available. The proportion of all HIV-related deaths among persons newly diagnosed with HIV during the terminal hospitalization decreased from 93% during 1997-1999 to 28% during 2003-2005. Opportunistic infection was at least one of the causes of death in nearly half of all cases.

CONCLUSIONS

Although, the HIV-specific death rates have declined significantly since the introduction of highly active antiretroviral therapy, HIV infection continues to contribute to the premature deaths among adults, mainly because of the late presentation.

摘要

目的

比较高效抗逆转录病毒治疗引入前后的死亡率趋势及死亡原因。

方法

这是一项基于对1997年1月至2005年12月期间所有与HIV相关死亡病例图表回顾的回顾性研究。

结果

在有高效抗逆转录病毒治疗可用时，HIV特异性死亡率从1997 - 1999年期间每10万成年人口34.12例降至2003 - 2005年期间每10万成年人口17.21例。在终末期住院期间新诊断为HIV的患者中，所有与HIV相关死亡的比例从1997 - 1999年期间的93%降至2003 - 2005年期间的28%。机会性感染在几乎一半的病例中至少是死亡原因之一。