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是否存在经实证支持且具有临床实用性的酒精依赖亚型?

Are there empirically supported and clinically useful subtypes of alcohol dependence?

作者信息

Hesselbrock Victor M, Hesselbrock Michie N

机构信息

Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT, USA.

出版信息

Addiction. 2006 Sep;101 Suppl 1:97-103. doi: 10.1111/j.1360-0443.2006.01596.x.

Abstract

AIMS

This paper provides an overview of several multidimensional empirically derived typologies of alcohol use disorders that have been derived primarily for research purposes in relation to their clinical utility.

METHODS

Studies using multivariate statistical methods for identifying homogeneous groups of subjects were selected for inclusion. Theoretically based typologies were not included in this review.

RESULTS

While formal diagnostic criteria typically identify separate categories of alcohol abuse and dependence, several studies using different statistical methods consistently suggest as many as four homogeneous types of alcoholism: a chronic/severe type, a depressed/anxious type, a mildly affected type and an antisocial type.

CONCLUSIONS

Even though the longitudinal outcomes of few empirically derived subtypes have been examined, alcoholism typologies remain a viable and potentially valuable tool for investigating etiological pathways, the effectiveness of treatments and the long-term course of alcohol use disorders.

摘要

目的

本文概述了几种主要为研究目的而得出的酒精使用障碍的多维实证类型,并探讨了其临床实用性。

方法

选择使用多元统计方法识别同质受试者群体的研究纳入。基于理论的类型未纳入本综述。

结果

虽然正式诊断标准通常将酒精滥用和依赖分为不同类别,但多项使用不同统计方法的研究一致表明,多达四种同质类型的酒精中毒:慢性/重度型、抑郁/焦虑型、轻度受影响型和反社会型。

结论

尽管很少有实证得出的亚型的纵向结果得到研究,但酒精中毒类型仍然是研究病因途径、治疗效果和酒精使用障碍长期病程的可行且潜在有价值的工具。

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