Department of Psychiatry, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary.
Doctoral School of Psychology, ELTE Eötvös Loránd University, Budapest, Hungary.
PLoS One. 2022 Mar 18;17(3):e0265577. doi: 10.1371/journal.pone.0265577. eCollection 2022.
Higher levels of externalizing characteristics, i.e. impulsivity, novelty seeking and aggression, could contribute to the development, progression and severity of alcohol use disorder (AUD). The present study aims to explore whether these externalizing characteristics together have a potential group-forming role in AUD using latent profile analysis (LPA).
Externalizing characteristics of 102 AUD patients were analyzed using LPA to explore the group-forming role of externalizing symptoms; groups were compared in terms of demographic and alcohol-related variables, indices of psychopathological, depressive and anxiety symptom severity.
LPA revealed and supported a two-group model based on externalizing symptoms. The group with higher levels of externalizing symptoms showed significantly elevated levels of alcohol-related and anxio-depressive symptoms.
Externalizing characteristics converge and have a group-forming role in chronic AUD, and are associated with a more severe form of AUD. By making the diagnostic category less heterogeneous, these different subtypes within AUD may provide aid in tailoring treatments to patients' specific needs.
更高水平的外化特征，即冲动、寻求新奇和攻击性，可能会导致酒精使用障碍（AUD）的发展、进展和严重程度增加。本研究旨在使用潜在剖面分析（LPA）探索这些外化特征是否共同在外 AUD 中具有潜在的分组作用。
使用 LPA 分析 102 名 AUD 患者的外化特征，以探索外化症状的分组作用；比较两组在人口统计学和酒精相关变量、精神病理、抑郁和焦虑症状严重程度指标方面的差异。
LPA 揭示并支持了基于外化症状的两分组模型。具有更高外化症状水平的组表现出明显更高的酒精相关和焦虑抑郁症状水平。
外化特征在外 AUD 中汇聚并具有分组作用，与更严重的 AUD 形式相关。通过使诊断类别更具同质性，这些 AUD 中的不同亚型可能有助于根据患者的具体需求定制治疗。
