重复经颅磁刺激和经颅直流电刺激诱导的短暂性耳鸣抑制
Transient tinnitus suppression induced by repetitive transcranial magnetic stimulation and transcranial direct current stimulation.
作者信息
Fregni F, Marcondes R, Boggio P S, Marcolin M A, Rigonatti S P, Sanchez T G, Nitsche M A, Pascual-Leone A
机构信息
Harvard Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
出版信息
Eur J Neurol. 2006 Sep;13(9):996-1001. doi: 10.1111/j.1468-1331.2006.01414.x.
Modulation of activity in the left temporoparietal area (LTA) by 10 Hz repetitive transcranial magnetic stimulation (rTMS) results in a transient reduction of tinnitus. We aimed to replicate these results and test whether transcranial direct current stimulation (tDCS) of LTA could yield similar effect. Patients with tinnitus underwent six different types of stimulation in a random order: 10-Hz rTMS of LTA, 10-Hz rTMS of mesial parietal cortex, sham rTMS, anodal tDCS of LTA, cathodal tDCS of LTA and sham tDCS. A non-parametric analysis of variance showed a significant main effect of type of stimulation (P = 0.002) and post hoc tests showed that 10-Hz rTMS and anodal tDCS of LTA resulted in a significant reduction of tinnitus. These effects were short lasting. These results replicate the findings of the previous study and, in addition, show preliminary evidence that anodal tDCS of LTA induces a similar transient tinnitus reduction as high-frequency rTMS.
通过10赫兹重复经颅磁刺激（rTMS）调节左颞顶叶区域（LTA）的活动会导致耳鸣短暂减轻。我们旨在重复这些结果，并测试LTA的经颅直流电刺激（tDCS）是否能产生类似效果。耳鸣患者以随机顺序接受六种不同类型的刺激：LTA的10赫兹rTMS、内侧顶叶皮质的10赫兹rTMS、伪rTMS、LTA的阳极tDCS、LTA的阴极tDCS和伪tDCS。非参数方差分析显示刺激类型有显著的主效应（P = 0.002），事后检验表明LTA的10赫兹rTMS和阳极tDCS导致耳鸣显著减轻。这些效应持续时间较短。这些结果重复了先前研究的发现，此外，还显示了初步证据，即LTA的阳极tDCS与高频rTMS一样能诱导类似的短暂耳鸣减轻。
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