一种来自产黄顶孢霉的具有抗菌活性的夫西地酸类似物。
An antibacterial hydroxy fusidic acid analogue from Acremonium crotocinigenum.
作者信息
Evans Liam, Hedger John N, Brayford David, Stavri Michael, Smith Eileen, O'Donnell Gemma, Gray Alexander I, Griffith Gareth W, Gibbons Simon
机构信息
Hypha Discovery Ltd., School of Biosciences, University of Westminster, 115 New Cavendish Street, London W1W 6UW, UK.
出版信息
Phytochemistry. 2006 Oct;67(19):2110-4. doi: 10.1016/j.phytochem.2006.06.033. Epub 2006 Aug 22.
A fusidane triterpene, 16-deacetoxy-7-beta-hydroxy-fusidic acid (1), was isolated from a fermentation of the mitosporic fungus Acremonium crotocinigenum. Full unambiguous assignment of all (1)H and (13)C data of 1 was carried out by extensive one- and two-dimensional NMR studies employing HMQC and HMBC spectra. Compound 1 was tested against a panel of multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus (MRSA) strains and showed minimum inhibitory concentration values of 16 microg/ml.
从产孢丝状真菌头孢菌素头孢霉的发酵产物中分离出一种梭链烷三萜，16-脱乙酰氧基-7-β-羟基梭链孢酸（1）。通过使用HMQC和HMBC谱的广泛一维和二维核磁共振研究，对化合物1的所有氢和碳数据进行了完整明确的归属。化合物1针对一组多药耐药（MDR）和耐甲氧西林金黄色葡萄球菌（MRSA）菌株进行了测试，显示最低抑菌浓度值为16微克/毫升。
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