HIV在体外对单核细胞/巨噬细胞的感染。
Infection of monocytes/macrophages by HIV in vitro.
作者信息
von Briesen H, Andreesen R, Esser R, Brugger W, Meichsner C, Becker K, Rübsamen-Waigmann H
机构信息
Georg-Speyer-Haus, Chemotherapeutisches Forschungsinstitut, Frankfurt/M, FRG.
出版信息
Res Virol. 1990 Mar-Apr;141(2):225-31. doi: 10.1016/0923-2516(90)90025-e.
Because of the very important role of the mononuclear phagocyte system in the immunopathogenesis of HIV infection, a culture system for in vitro studies of infection of monocytes/macrophages with HIV was developed. A method is described for the infection of human monocytes/macrophages cultured on hydrophobic membranes (Teflon) with different strains of HIV. The HIV isolates can be characterized according to their replication potential on monocytes/macrophages cultures. The biological properties of some HIV1 and HIV2 isolates are compared in lymphocyte and monocyte/macrophage cultures.
由于单核吞噬细胞系统在HIV感染的免疫发病机制中起着非常重要的作用，因此开发了一种用于体外研究HIV感染单核细胞/巨噬细胞的培养系统。本文描述了一种用不同HIV毒株感染培养在疏水膜（聚四氟乙烯）上的人单核细胞/巨噬细胞的方法。HIV分离株可根据其在单核细胞/巨噬细胞培养物上的复制潜力进行表征。在淋巴细胞和单核细胞/巨噬细胞培养物中比较了一些HIV-1和HIV-2分离株的生物学特性。
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