在已建立的人脑细胞培养物中与髓鞘形成相关酶的展示。
Demonstration of enzymes related to myelinogenesis in established human brain cell cultures.
作者信息
Duch D, Mandel P, Koprowski H
出版信息
J Neurol Sci. 1975 Sep;26(1):99-105. doi: 10.1016/0022-510x(75)90117-3.
PMID:169328
Abstract
CNP, CGalT and PAPS-CST, enzymes involved in myelinogenesis were demonstrated in cultures derived from human brain. Little or no CNP activity could be found in cultures derived from non-neurogenic tissue. Transformation of brain cultures by PML-SV40 virus resulted in a 3 to 10-fold increase in the specific activity of CNP.
摘要
参与髓鞘形成的酶——2',3'-环核苷酸 3'-磷酸二酯酶（CNP）、半乳糖基转移酶（CGalT）和3'-磷酸腺苷-5'-磷酰硫酸-酪蛋白硫酸转移酶（PAPS-CST）在源自人脑的培养物中得到了证实。在源自非神经源性组织的培养物中几乎检测不到或没有CNP活性。用早幼粒细胞白血病病毒-猴病毒40（PML-SV40）病毒转化脑培养物会导致CNP的比活性增加3至10倍。
Zotero 插件