Sena A, Sarliève L L, Rebel G
J Neurol Sci. 1985 May;68(2-3):233-43. doi: 10.1016/0022-510x(85)90104-2.
Brain myelin was studied in genetically obese (ob/ob) mice and compared with that of normal (+/+) mice from the same strain. The brain from obese mice had a significantly lower amount of myelin, and marked changes in the fatty acid composition of myelin were observed. In contrast, the myelin cholesterol: phospholipid: galactolipid and the cerebroside: sulfatide molar ratios and also the phospholipid composition were normal. 2',3'-Cyclic nucleotide 3'-phosphohydrolase (CNP) and UDP-galactose ceramide galactosyltransferase (CGalT) enzymatic activities were normal, and 3'-phosphoadenosine 5'-phosphosulfate (PAPS): cerebroside sulfotransferase (CST) was only slightly decreased. Cholesterol esters were not present in the mutant. These results indicate that brain myelination is affected in obese mutant mice.
对遗传性肥胖（ob/ob）小鼠的脑髓磷脂进行了研究，并与同一品系的正常（+/+）小鼠进行了比较。肥胖小鼠的脑髓磷脂含量显著降低，并且观察到髓磷脂脂肪酸组成有明显变化。相比之下，髓磷脂胆固醇：磷脂：半乳糖脂以及脑苷脂：硫脂的摩尔比以及磷脂组成均正常。2',3'-环核苷酸3'-磷酸水解酶（CNP）和UDP-半乳糖神经酰胺半乳糖基转移酶（CGalT）的酶活性正常，3'-磷酸腺苷5'-磷酸硫酸酯（PAPS）：脑苷脂硫酸转移酶（CST）仅略有降低。突变体中不存在胆固醇酯。这些结果表明肥胖突变小鼠的脑髓鞘形成受到影响。
