Müller T, Welnic J, Muhlack S
Department of Neurology, St. Josef Hospital, Ruhr University Bochum, Bochum, Germany.
J Neural Transm (Vienna). 2007 Mar;114(3):347-50. doi: 10.1007/s00702-006-0552-0. Epub 2006 Aug 24.
Levodopa (LD) application improves motor symptoms in patients with Parkinson's disease (PD) patients. Little is known on further effects of LD, which induced lower plasma levels of cortisol and lower serotonergic activity in certain brain areas of fish. Objectives of this trial were to analyse levels of cortisol, LD and 3-O-methyldopa (3-OMD) after administration of LD/benserazide in long term treated PD patients. 12 PD patients, taken off their regular treatment for at least 12 hours, received soluble 200 mg LD/50 mg benserazide under stress free conditions. Motor symptoms improved, LD and 3-OMD levels increased, whereas cortisol concentrations started to decrease significantly 30 minutes after LD intake. This reduced cortisol release may result from an overflow of exogenous LD in the brainstem. This hypothetically causes an reduced 5-HT content in neurons projecting to the hypothalamic structures, which are involved in the partial 5-HT dependent central regulation of peripheral cortisol release.
左旋多巴（LD）的应用可改善帕金森病（PD）患者的运动症状。关于LD的进一步影响知之甚少，LD可导致鱼类某些脑区的血浆皮质醇水平降低和血清素能活性降低。本试验的目的是分析长期治疗的PD患者服用LD/苄丝肼后皮质醇、LD和3 - O - 甲基多巴（3 - OMD）的水平。12名PD患者在至少停药12小时后，在无应激条件下接受了200毫克可溶性LD/50毫克苄丝肼。运动症状改善，LD和3 - OMD水平升高，而皮质醇浓度在摄入LD后30分钟开始显著下降。这种皮质醇释放减少可能是由于脑干中外源性LD的溢出所致。这假设性地导致投射到下丘脑结构的神经元中5 - HT含量减少，而下丘脑结构参与了外周皮质醇释放的部分5 - HT依赖性中枢调节。
