Ohri Anupam, Jetly Dhaval, Shukla Kaushambi, Bansal Rimpi
Department of Pathology, Gujarat Cancer and Research Institute, Ahmedabad.
Indian J Pathol Microbiol. 2006 Apr;49(2):208-13.
Cytological grading of breast cancer is not well established despite histological grading having gained a strong foothold. In our study we have analyzed 50 cases of breast carcinoma which included invasive ductal carcinoma, invasive lobular carcinoma, mucinous carcinoma, stromal sarcoma, apocrine carcinoma, papillary carcinoma. Papanicolaou smears were graded according to established Hunt's, Simplified Black and Modified Black grading systems. They were then compared with the Scarff Bloom Richardson grading system. Simplified Black grading system has been recommended for cytological grading of breast neoplasia because of its lucidity and its reproducibility. Cytological grading of breast neoplasia is important for neo adjuvant chemotherapy and also for predicting the prognosis of the patient on FNAC alone. Incorporation of other parameters like apoptosis and bcl-2 is also recommended.
尽管组织学分级已站稳脚跟，但乳腺癌的细胞学分级尚未完全确立。在我们的研究中，我们分析了50例乳腺癌病例，其中包括浸润性导管癌、浸润性小叶癌、黏液癌、间质肉瘤、大汗腺癌、乳头状癌。巴氏涂片根据既定的亨特分级系统、简化布莱克分级系统和改良布莱克分级系统进行分级。然后将它们与斯卡夫-布卢姆-理查森分级系统进行比较。简化布莱克分级系统因其清晰性和可重复性而被推荐用于乳腺肿瘤的细胞学分级。乳腺肿瘤的细胞学分级对于新辅助化疗以及仅通过细针穿刺抽吸活检（FNAC）预测患者的预后都很重要。还建议纳入其他参数，如细胞凋亡和bcl-2。
