Pandey Pinki, Dixit Alok, Chandra Subrat, Kaur Swarn
Department of Pathology, U. P. Rural Institute of Medical Sciences & Research, Saifai, Etawah 206301, India.
Department of Pharmacology, U. P. Rural Institute of Medical Sciences & Research, Saifai, Etawah 206301, India.
Anal Cell Pathol (Amst). 2014;2014:767215. doi: 10.1155/2014/767215. Epub 2014 Dec 8.
Cytonuclear gradings in the breast carcinoma raise the level of FNA reportage and improves patient management. Our aim was to evaluate and compare two cytological grading methods (Robinson's and Mouriquand's) in breast carcinoma and correlate it with Nottingham modification of Scarff-Bloom-Richardson (SBR) histological grading.
30 cytologically proven cases of infiltrating ductal carcinoma were graded cytologically and histologically. Cytograding was done by Robinson's and Mouriquand's methods (grades I to III) followed by comparison of the two methods. Cytogradings were correlated with SBR grading method. Sensitivity, specificity, diagnostic accuracy, and concordance and discordance rates were evaluated.
An overall concordance of 76.66% between cytogradings, of 83.33% between Robinson's method and SBR, and of 66.66% between Mouriquand's method and SBR was seen. Robinson's method correlated best with SBR in all the three nuclear grades. Robinson's method showed a diagnostic accuracy of 90% with 91.30% sensitivity while Mouriquand's method had an accuracy of 76.66% with 95.65% sensitivity. The specificity by Mouriquand's method was quite low (14.28%) as compared to Robinson's method (85.71%).
Comprehensive cytological grading of breast cancer by Robinson's method seems better because of more objective set of criteria, easy reproducibility, and specificity.
乳腺癌的细胞核分级提高了细针穿刺活检（FNA）报告的水平并改善了患者管理。我们的目的是评估和比较乳腺癌的两种细胞学分级方法（罗宾逊法和穆里昆德法），并将其与诺丁汉改良的斯卡夫-布卢姆-理查森（SBR）组织学分级相关联。
对30例经细胞学证实的浸润性导管癌病例进行细胞学和组织学分级。采用罗宾逊法和穆里昆德法进行细胞分级（I至III级），然后比较这两种方法。将细胞分级与SBR分级方法相关联。评估敏感性、特异性、诊断准确性以及一致性和不一致率。
细胞分级之间的总体一致性为76.66%，罗宾逊法与SBR之间为83.33%，穆里昆德法与SBR之间为66.66%。在所有三个核分级中，罗宾逊法与SBR的相关性最佳。罗宾逊法的诊断准确性为90%，敏感性为91.30%，而穆里昆德法的准确性为76.66%，敏感性为95.65%。与罗宾逊法（85.71%）相比，穆里昆德法的特异性相当低（14.28%）。
由于罗宾逊法的标准更客观、易于重复且具有特异性，因此通过该方法对乳腺癌进行全面的细胞学分级似乎更好。
