Kieffer M, Bergbrant I M, Faergemann J, Jemec G B, Ottevanger V, Stahl Skov P, Svejgaard E
Department of Dermatology, University of Copenhagen, Gentofte Hospital, Hellerup, Denmark.
J Am Acad Dermatol. 1990 May;22(5 Pt 1):739-42. doi: 10.1016/0190-9622(90)70100-v.
Pityrosporum ovale is a lipophilic yeast commonly present in the seborrheic areas of the skin of adults. Fifty-five young adult patients with atopic dermatitis, 19 patients with seborrheic dermatitis, and 19 healthy control subjects were examined for immune reactions to P. ovale, including tests for specific IgE antibodies (prick test, histamine release), IgG antibodies and epicutaneous testing. IgE antibodies against P. ovale were found in two thirds of the patients with atopic dermatitis and were more frequent in patients with lesions predominantly in the seborrheic areas. In addition, some atopic patients had positive reactions to epicutaneous tests, which suggest that delayed allergic reactions to P. ovale may also be important. In patients with seborrheic dermatitis, no evidence of immediate or delayed hypersensitivity to P. ovale was found. IgG antibody levels were low in all groups.
卵圆形糠秕孢子菌是一种亲脂性酵母，常见于成人皮肤的脂溢部位。对55名患有特应性皮炎的年轻成年患者、19名患有脂溢性皮炎的患者以及19名健康对照者进行了针对卵圆形糠秕孢子菌的免疫反应检测，包括特异性IgE抗体检测（点刺试验、组胺释放试验）、IgG抗体检测和皮内试验。三分之二的特应性皮炎患者体内发现了抗卵圆形糠秕孢子菌的IgE抗体，且在主要位于脂溢部位有皮损的患者中更为常见。此外，一些特应性患者皮内试验呈阳性反应，这表明对卵圆形糠秕孢子菌的迟发性过敏反应可能也很重要。在脂溢性皮炎患者中，未发现对卵圆形糠秕孢子菌有速发型或迟发型超敏反应的证据。所有组的IgG抗体水平均较低。
