Wallace M, Luine V, Arellanos A, Frankfurt M
Graduate Center, CUNY, New York, NY 10016, USA.
Brain Res. 2006 Dec 18;1126(1):176-82. doi: 10.1016/j.brainres.2006.07.064. Epub 2006 Aug 24.
Effects of ovariectomy (OVX) on performance of the memory tasks, Object Recognition (OR) and Object Placement (OP), and on dendritic spine density in pyramidal neurons in layer II/III of the prefrontal cortex and the CA1 and CA3 regions of the hippocampus were determined. OVX was associated with a significant decline in performance of the memory tasks as compared to intact rats beginning at 1 week post OVX for OR and 4 weeks post OVX for OP. Golgi impregnation at 7 weeks post OVX showed significantly lower spine densities (17-53%) in the pyramidal neurons of the medial prefrontal cortex and the CA1, but not the CA3, region of the hippocampus in OVX compared to intact rats. These results suggest that cognitive impairments observed in OVX rats may be associated with morphological changes in brain areas mediating memory.
研究了卵巢切除术（OVX）对记忆任务表现（物体识别（OR）和物体放置（OP））以及前额叶皮层II/III层、海马体CA1和CA3区锥体细胞树突棘密度的影响。与完整大鼠相比，OVX大鼠在OR任务中，术后1周开始，在OP任务中，术后4周开始，记忆任务表现显著下降。OVX术后7周进行高尔基染色显示，与完整大鼠相比，OVX大鼠内侧前额叶皮层和海马体CA1区（而非CA3区）的锥体细胞树突棘密度显著降低（17 - 53%）。这些结果表明，在OVX大鼠中观察到的认知障碍可能与介导记忆的脑区形态变化有关。
