Barrett Christian L, Kim Tae Yong, Kim Hyun Uk, Palsson Bernhard Ø, Lee Sang Yup
Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.
Curr Opin Biotechnol. 2006 Oct;17(5):488-92. doi: 10.1016/j.copbio.2006.08.001. Epub 2006 Aug 23.
As the ambitions of synthetic biology approach genome-scale engineering, comprehensive characterization of cellular systems is required, as well as a means to accurately model cell-scale molecular interactions. These requirements are coincident with the goals of systems biology and, thus, systems biology will become the foundation for genome-scale synthetic biology. Systems biology will form this foundation through its efforts to reconstruct and integrate cellular systems, develop the mathematics, theory and software tools for the accurate modeling of these integrated systems, and through evolutionary mechanisms. As genome-scale synthetic biology is so enabled, it will prove to be a positive feedback driver of systems biology by exposing and forcing researchers to confront those aspects of systems biology which are inadequately understood.
随着合成生物学的目标朝着基因组规模工程发展，需要对细胞系统进行全面表征，以及一种准确模拟细胞尺度分子相互作用的方法。这些要求与系统生物学的目标一致，因此，系统生物学将成为基因组规模合成生物学的基础。系统生物学将通过努力重建和整合细胞系统、开发用于准确建模这些整合系统的数学、理论和软件工具以及通过进化机制来奠定这一基础。由于基因组规模合成生物学因此得以实现，它将通过揭示并迫使研究人员面对系统生物学中那些理解不足的方面，从而被证明是系统生物学的一个正反馈驱动因素。
