Tait Sabrina, Salvati Anna Laura, Desideri Nicoletta, Fiore Lucia
Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome 00161, Italy.
Antiviral Res. 2006 Dec;72(3):252-5. doi: 10.1016/j.antiviral.2006.07.003. Epub 2006 Jul 28.
The antiviral activity of homoisoflavonoids, a class of flavonoids, was determined in vitro against a large panel of enteroviruses. The inhibition of viral replication was monitored on BGM (Buffalo Green Monkey) cells, and the concentration required for 50% inhibition (IC50), as well as the selectivity index (SI) were determined. None of the substances were effective against Sabin type 1 poliovirus (PV1), but most of them showed a low cytotoxicity and a marked antiviral activity against Coxsackie virus B1, B3, B4, A9 and echovirus 30.
一类黄酮类化合物即高异黄酮类化合物的抗病毒活性在体外针对大量肠道病毒进行了测定。在BGM（水牛绿猴）细胞上监测病毒复制的抑制情况，并确定50%抑制所需浓度（IC50）以及选择性指数（SI）。这些物质均对1型萨宾脊髓灰质炎病毒（PV1）无效，但它们中的大多数显示出低细胞毒性以及对柯萨奇病毒B1、B3、B4、A9和埃可病毒30具有显著的抗病毒活性。
