Oréfice Juliana L, Costa Rogério A, Campos Wesley, Calucci Daniela, Scott Ingrid U, Oréfice Fernando
Uveitis Section, Department of Ophthalmology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Am J Ophthalmol. 2006 Sep;142(3):503-5. doi: 10.1016/j.ajo.2006.03.037.
To investigate optical coherence tomography (OCT) findings in patients with punctate retinal toxoplasmosis (PRT).
Observational case series.
Tertiary ophthalmic referral center.
Four patients with PRT consecutively evaluated between July 2004 and June 2005.
Clinical examination and OCT.
Morphologic features at baseline and changes within a 24-week follow-up interval.
Retinal layers were abnormally hyperreflective at the active lesion site and associated with some degree of retinal pigment epithelium-choriocapillaris/choroidal optical shadowing in all patients. The posterior hyaloid was thickened and focally detached (over the lesion). Additional findings include tractional maculopathy (n = 2) and diffuse macular edema (n = 1). During follow-up, focal choriocapillaris/choroidal relative hyperreflectivity was observed at the former lesion site, and posterior vitreous detachment progressed in all patients.
Our findings suggest that OCT may enable identification of subtle morphologic features previously underappreciated in patients with PRT, which may provide new insights about the disease pathophysiologic mechanisms.
研究点状视网膜弓形虫病（PRT）患者的光学相干断层扫描（OCT）表现。
观察性病例系列。
三级眼科转诊中心。
2004年7月至2005年6月期间连续评估的4例PRT患者。
临床检查和OCT。
基线时的形态学特征以及24周随访期内的变化。
所有患者在活动性病变部位视网膜各层均出现异常高反射，并伴有一定程度的视网膜色素上皮-脉络膜毛细血管/脉络膜光学暗影。后玻璃体增厚并在病变部位局部脱离。其他发现包括牵拉性黄斑病变（n = 2）和弥漫性黄斑水肿（n = 1）。随访期间，在先前病变部位观察到局灶性脉络膜毛细血管/脉络膜相对高反射，所有患者后玻璃体脱离均有进展。
我们的研究结果表明，OCT可能有助于识别PRT患者以前未被充分认识的细微形态学特征，这可能为该疾病的病理生理机制提供新的见解。
