马立克氏病疱疹病毒在缺乏内源性（gs、鸡辅助因子、劳氏相关病毒-O）和外源性禽RNA肿瘤病毒表达的鸡中的致癌作用。
Oncogenesis by Marek's disease herpesvirus in chickens lacking expression of endogenous (gs, chick helper factor, Rous-associated virus-O) and exogenous avian RNA tumor viruses.
作者信息
Witter R L, Lee L F, Okazaki W, Purchase H G, Burmester B R, Luginbuhl R E
出版信息
J Natl Cancer Inst. 1975 Jul;55(1):215-8. doi: 10.1093/jnci/55.1.215.
Chickens free of exogenous avian leukosis virus (ALV) infection, replicating endogenous ALV (Rous-associated virus-O), gs antigen, and chick helper factor were fully susceptible to induction of Marek's disease (MD) by ALV-free MD viruses. Dual infection with Rous-associated virus-2 and MD virus did not significantly alter the character of the MD lesions. Thus exogenous ALV infection was not requisite for MD virus-induced oncogenesis. Although participation of endogenous RNA tumor virus genes in MD lesion induction could not be excluded, expression of such genes in MD tumors as gs antigen was not established.
未感染外源性禽白血病病毒（ALV）、能复制内源性ALV（劳斯相关病毒-O）、gs抗原和鸡辅助因子的鸡，对无ALV的马立克氏病（MD）病毒诱导MD完全易感。劳斯相关病毒-2和MD病毒双重感染并未显著改变MD病变的特征。因此，外源性ALV感染并非MD病毒诱导肿瘤发生所必需。虽然不能排除内源性RNA肿瘤病毒基因参与MD病变诱导，但尚未证实此类基因在MD肿瘤中如gs抗原的表达。
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