Angadi C V
Department of Pathology, Nassau County Medical Center, Stony Brook, East Meadow, New York.
J Clin Lab Anal. 1990;4(3):193-5. doi: 10.1002/jcla.1860040309.
Human T-helper cells express membrane-bound CD4 antigen whose many epitopes are recognized by different monoclonal antibodies. The epitope recognized by Leu-3a and similar clones has been shown to be the location for human immunodeficiency virus (HIV) receptor. We have found a unique blood donor whose CD4+ T-helper lymphocytes were lacking Leu-3a epitope. CD4+ T-helper cells lacking Leu-3a epitope might be resistant to HIV infection.
人类辅助性T细胞表达膜结合型CD4抗原，其许多表位可被不同的单克隆抗体识别。已证明Leu-3a及类似克隆所识别的表位是人类免疫缺陷病毒（HIV）受体的所在位置。我们发现了一位独特的献血者，其CD4⁺辅助性T淋巴细胞缺乏Leu-3a表位。缺乏Leu-3a表位的CD4⁺辅助性T细胞可能对HIV感染具有抗性。
