遗传性非息肉病性结直肠癌家族中女性对妇科监测的认识。

Awareness of gynecologic surveillance in women from hereditary non-polyposis colorectal cancer families.

作者信息

Yang Kathleen, Allen Brian, Conrad Peggy, Powell C Bethan, Terdiman Jonathan, Chen Lee-may

机构信息

Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Reproductive Sciences, UCSF Comprehensive Cancer Center, 1600 Divisadero St., 4th Floor, San Francisco, CA 94115, USA.

出版信息

Fam Cancer. 2006;5(4):405-9. doi: 10.1007/s10689-006-0012-x. Epub 2006 Aug 26.

DOI:10.1007/s10689-006-0012-x

PMID:16937235

Abstract

OBJECTIVE

To determine knowledge of gynecologic cancer risk and screening in women with HNPCC.

STUDY DESIGN

Forty-three women with HNPCC were counseled through a gastrointestinal cancer risk program, and later sent a questionnaire regarding their screening practices for gynecologic neoplasms.

RESULTS

Twenty-seven (63%) of 43 responded. Fifteen (55%) of 27 had previously been diagnosed with cancer. Among 16 women with a uterus, 11 (69%) reported surveillance by ultrasound or endometrial sampling. Among 21 respondents with ovaries, 13 (62%) reported screening by ultrasound or CA125. Twenty-two (81%) of 27 had seen a gynecologist after receiving their HNPCC diagnosis, but only 12% recalled hearing about risks from their gynecologist, and 8% from their gynecologic oncologist. Genetic counselors were cited as the most common source (48%) of gynecologic cancer risk information.

CONCLUSIONS

While the effectiveness of surveillance remains in question, gynecologists can be a source of information regarding gynecologic cancer risk for women from HNPCC families.

摘要

目的

确定遗传性非息肉病性结直肠癌（HNPCC）女性患者对妇科癌症风险及筛查的了解情况。

研究设计

通过一项胃肠道癌症风险项目对43名HNPCC女性患者进行咨询，随后向她们发送了一份关于其妇科肿瘤筛查做法的调查问卷。

结果

43名患者中有27名（63%）做出回应。27名患者中有15名（55%）之前被诊断患有癌症。在16名有子宫的女性中，11名（69%）报告通过超声或子宫内膜取样进行监测。在21名有卵巢的受访者中，13名（62%）报告通过超声或CA125进行筛查。27名患者中有22名（81%）在被诊断为HNPCC后看过妇科医生，但只有12%的人记得从妇科医生那里听说过相关风险，8%的人记得从妇科肿瘤医生那里听说过。遗传咨询师被认为是妇科癌症风险信息最常见的来源（48%）。