Broaddus Russell R, Lu Karen H
Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.
Front Biosci. 2006 Sep 1;11:2077-80. doi: 10.2741/1950.
Hereditary nonpolyposis colorectal cancer syndrome (HNPCC) is an autosomal-dominant inherited cancer susceptibility syndrome that is associated with increased risk of development of endometrial and ovarian cancers. Therefore, women with HNPCC are candidates for chemoprevention of gynecological cancers. Although there have been a number of clinical trials examining chemoprevention strategies for colorectal cancer in HNPCC, the information regarding gynecological cancers in HNPCC remains limited. The purpose of this review is to provide an analytical background about the current knowledge regarding gynecological cancers in patients with HNPCC.
遗传性非息肉病性结直肠癌综合征（HNPCC）是一种常染色体显性遗传的癌症易感性综合征，与子宫内膜癌和卵巢癌的发病风险增加相关。因此，患有HNPCC的女性是妇科癌症化学预防的候选对象。尽管已经有多项临床试验研究HNPCC患者结直肠癌的化学预防策略，但关于HNPCC患者妇科癌症的信息仍然有限。本综述的目的是提供关于HNPCC患者妇科癌症现有知识的分析背景。
