He Ying-Li, Zhao Ying-Ren, Zhang Shu-Lin, Lin Shu-Mei
Department of Infectious Diseases, the First Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.
World J Gastroenterol. 2006 Aug 14;12(30):4788-93. doi: 10.3748/wjg.v12.i30.4788.
Genetic epidemiology researches such as twin studies, family-clustering of hepatitis B virus (HBV) infection studies and ethnic difference studies have provided the evidence that host genetic factors play an important role in determining the outcome of HBV infection. The opening questions include which human genes are important in infection and how to find them. Though a number of studies have sought genetic associations between HBV infection/persistence and gene polymorphisms, the candidate gene-based approach is clearly inadequate to fully explain the genetic basis of the disease. With the advent of new genetic markers and automated genotyping, genetic mapping can be conducted extremely rapid. This approach has been successful in some infectious diseases. Linkage analysis can find host genes susceptible to HBV and is of great clinical importance.
诸如双胞胎研究、乙型肝炎病毒（HBV）感染的家族聚集性研究以及种族差异研究等遗传流行病学研究已经提供了证据，表明宿主遗传因素在决定HBV感染的结果中起着重要作用。首要问题包括哪些人类基因在感染中很重要以及如何找到它们。尽管许多研究已经探寻了HBV感染/持续存在与基因多态性之间的遗传关联，但基于候选基因的方法显然不足以充分解释该疾病的遗传基础。随着新的遗传标记和自动化基因分型技术的出现，遗传图谱绘制可以极其迅速地进行。这种方法在一些传染病中已经取得了成功。连锁分析可以找到对HBV易感的宿主基因，并且具有重要的临床意义。
