Wagner Hermann
Institute of Medical Microbiology, Immunology and Hygiene, 81675 Munich, Germany.
Adv Immunol. 2006;91:159-73. doi: 10.1016/S0065-2776(06)91004-9.
Based on an evolutionary conserved repertoire Toll-like-receptors (TLRs) donate specificity to innate immune cells. Therefore, TLRs are considered as paradigmatic for "self" versus "non-self" discrimination. This view, however, needs to be modified since TLR's also appear to recognise "endogeneous", that is host-derived ligands, examples being host-derived DNA and -RNA. Here I discuss physiological and pathophysiological consequences of endogeneous ligand-recognition by TLRs. I conclude that endogeneous ligand recognition by TLRs drives sterile inflammation sustained by innate immune cells in certain autoimmune disorders.
基于进化保守的模式识别受体库，Toll样受体（TLRs）赋予先天免疫细胞特异性。因此，TLRs被视为区分“自身”与“非自身”的典范。然而，这种观点需要修正，因为TLRs似乎也能识别“内源性”，即宿主来源的配体，例如宿主来源的DNA和RNA。在此，我将讨论TLRs识别内源性配体的生理和病理生理后果。我的结论是，在某些自身免疫性疾病中，TLRs识别内源性配体可引发由先天免疫细胞维持的无菌性炎症。
