Kim Ji Young, Jung Kyung Jin, Choi Jae Sue, Chung Hae Young
College of Pharmacy, Pusan National University, Busan, Korea.
Aging Cell. 2006 Oct;5(5):401-11. doi: 10.1111/j.1474-9726.2006.00233.x. Epub 2006 Aug 25.
Nuclear factor-kappaB (NF-kappaB), a redox-sensitive transcription factor, plays an important role in the aging process. Thus, developing and identifying specific components that modulate NF-kappaB without adverse side-effects would be of major importance. Hesperetin, a flavanone abundant in citrus fruits, has a variety of pharmacological properties being antioxidant, cholesterol-lowering, and anti-inflammatory. In this study, we investigated how hesperetin fed to 6- and 24-month-old rats modulates NF-kappaB in their kidneys. Results showed that hesperetin suppressed NF-kappaB activation and related gene expressions. An even more interesting finding is that hesperetin suppressed NF-kappaB through four signal transduction pathways, NIK/IKK, ERK, p38, and JNK. Further evidence showed the remarkable efficacy of hesperetin to suppress the translocation of Trx/Ref-1, indicating its beneficial effect on the redox status. The most significant findings of the current study report new information on the use of hesperetin as a potential anti-aging agent.
核因子-κB（NF-κB）是一种氧化还原敏感的转录因子，在衰老过程中起重要作用。因此，开发和鉴定能调节NF-κB且无不良副作用的特定成分至关重要。橙皮素是柑橘类水果中丰富的一种黄烷酮，具有多种药理特性，如抗氧化、降胆固醇和抗炎。在本研究中，我们研究了喂食6个月和24个月大鼠橙皮素如何调节其肾脏中的NF-κB。结果表明，橙皮素抑制NF-κB的激活及相关基因表达。一个更有趣的发现是，橙皮素通过NIK/IKK、ERK、p38和JNK这四条信号转导途径抑制NF-κB。进一步的证据表明橙皮素抑制Trx/Ref-1易位的显著功效，表明其对氧化还原状态的有益作用。本研究最重要的发现报告了关于使用橙皮素作为潜在抗衰老剂的新信息。
