Yari Zahra, Cheraghpour Makan, Hekmatdoost Azita
Student Research Committee, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Cancer Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Eur J Nutr. 2021 Feb;60(1):287-298. doi: 10.1007/s00394-020-02246-9. Epub 2020 Apr 15.
The aim of the present study was to compare the clinical effect of flaxseed and hesperidin alone and with combination in patients with metabolic syndrome. Number of participants with treated metabolic syndrome was assessed as a primary end point.
In this 12-week randomized controlled trial, ninety-eight patients with metabolic syndrome randomly assigned to receive either whole flaxseed powder (30 g/day), or hesperidin (1 g/day), or combination of 30 g flaxseed and 1 g hesperidin or no supplement while adhering a lifestyle modification program.
In comparison to control group, systolic blood pressure (- 5.68 vs. - 2.91 mmHg, P = 0.041) and serum concentrations of triglyceride (- 50.06 vs. 3.87 mg/dL, P = 0.033) in hesperidin group showed a significant reduction over 12 weeks of intervention. Comparison of the results of flaxseed group with the control group showed a significant improvement in serum concentrations of triglyceride (- 66 vs. 3.87 mg/dL, P = 0.028), insulin (- 4.27 vs. - 2.51 mU/L, P = 0.003) and accordingly insulin resistance (- 1.19 vs. - 0.76, P = 0.005) and sensitivity (0.03 vs. 0.01, P = 0.022) indices in flaxseed group. Combination of flaxseed and hesperidin improved three of five metabolic syndrome components including serum concentrations of triglyceride, glucose and systolic blood pressure as compared to placebo. Interestingly, co-administration of flaxseed and hesperidin with 77.3% reduction in the prevalence of defined metabolic syndrome was revealed to be most effective in controlling the metabolic syndrome, after which the group of flaxseed with 76% reduction and hesperidin group with 54.5% reduction were ranked second and third, respectively.
It can be concluded that co-administration of flaxseed and hesperidin appears to be superior to either supplementation alone on metabolic syndrome treatment, while the effects of flaxseed are stronger than hesperidin supplementation.
本研究旨在比较单独使用亚麻籽和橙皮苷以及两者联合使用对代谢综合征患者的临床效果。将接受治疗的代谢综合征患者数量作为主要终点进行评估。
在这项为期12周的随机对照试验中，98例代谢综合征患者被随机分配，分别接受全亚麻籽粉（30克/天）、橙皮苷（1克/天）、30克亚麻籽与1克橙皮苷的组合，或不补充任何物质，同时坚持生活方式改善计划。
与对照组相比，橙皮苷组在12周的干预期间，收缩压（-5.68对-2.91mmHg，P = 0.041）和血清甘油三酯浓度（-50.06对3.87mg/dL，P = 0.033）显著降低。亚麻籽组与对照组结果比较显示，亚麻籽组血清甘油三酯浓度（-66对3.87mg/dL，P = 0.028）、胰岛素（-4.27对-2.51mU/L，P = 0.003）以及相应的胰岛素抵抗（-1.19对-0.76，P = 0.005）和敏感性（0.03对0.01，P = 0.022）指数有显著改善。与安慰剂相比，亚麻籽和橙皮苷的组合改善了五个代谢综合征组分中的三个，包括血清甘油三酯、葡萄糖浓度和收缩压。有趣的是，亚麻籽和橙皮苷联合使用使确诊代谢综合征的患病率降低了77.3%，被证明在控制代谢综合征方面最有效，其次是亚麻籽组降低了76%，橙皮苷组降低了54.5%，分别排名第二和第三。
可以得出结论，亚麻籽和橙皮苷联合使用在代谢综合征治疗方面似乎优于单独补充任何一种，而亚麻籽的效果强于补充橙皮苷。
