Lewin C S, Amyes S G
Department of Bacteriology, Medical School, University of Edinburgh.
J Med Microbiol. 1990 Jun;32(2):83-6. doi: 10.1099/00222615-32-2-83.
Pefloxacin and fleroxacin showed biphasic bactericidal activity against Escherichia coli KL16 in nutrient broth. Bacteriostatic concentrations of chloramphenicol, an inhibitor of protein synthesis, and rifampicin, an inhibitor of RNA synthesis, could not completely abolish the bactericidal activity of either drug. Pefloxacin and fleroxacin were also active against non-dividing E. coli KL16. Therefore, pefloxacin and fleroxacin are able to kill bacteria which are not dividing nor actively synthesising protein or RNA.
培氟沙星和氟罗沙星在营养肉汤中对大肠杆菌KL16显示出双相杀菌活性。蛋白质合成抑制剂氯霉素和RNA合成抑制剂利福平的抑菌浓度不能完全消除这两种药物的杀菌活性。培氟沙星和氟罗沙星对非分裂状态的大肠杆菌KL16也有活性。因此，培氟沙星和氟罗沙星能够杀死既不分裂也不活跃合成蛋白质或RNA的细菌。
