在接受克林霉素治疗的小鼠中，质子泵抑制剂治疗抑制胃酸分泌会促进耐万古霉素肠球菌属和肺炎克雷伯菌在大肠中的定植。
Suppression of gastric acid production by proton pump inhibitor treatment facilitates colonization of the large intestine by vancomycin-resistant Enterococcus spp. and Klebsiella pneumoniae in clindamycin-treated mice.
作者信息
Stiefel Usha, Rao Agam, Pultz Michael J, Jump Robin L P, Aron David C, Donskey Curtis J
机构信息
Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, 10701 East Blvd., Cleveland, OH 44106, USA.
出版信息
Antimicrob Agents Chemother. 2006 Nov;50(11):3905-7. doi: 10.1128/AAC.00522-06. Epub 2006 Aug 28.
Abstract
Proton pump inhibitor treatment of clindamycin-treated mice elevated the gastric pH and facilitated the establishment of colonization of the large intestine by vancomycin-resistant Enterococcus spp. (75 to 80%, versus 20 to 25% for saline-treated controls) and Klebsiella pneumoniae (90%, versus 30% for saline-treated controls). These findings demonstrate a mechanism by which proton pump inhibitor therapy could contribute to the dissemination of nosocomial pathogens.
摘要
用质子泵抑制剂治疗经克林霉素处理的小鼠，会提高胃内pH值，并促进耐万古霉素肠球菌属（75%至80%，而生理盐水处理的对照组为20%至25%）和肺炎克雷伯菌（90%，而生理盐水处理的对照组为30%）在大肠中定殖。这些发现揭示了一种机制，通过该机制质子泵抑制剂疗法可能会促使医院病原体传播。
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