Cohen Craig R, Nosek Marcianna, Meier Amalia, Astete Sabina G, Iverson-Cabral Stefanie, Mugo Nelly R, Totten Patricia A
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, CA, USA.
Sex Transm Dis. 2007 May;34(5):274-9. doi: 10.1097/01.olq.0000237860.61298.54.
The objective of this study was to assess the risk factors for and persistence of Mycoplasma genitalium (MG) in a highly exposed female population in Kenya.
Two hundred fifty-eight sex workers in Nairobi, Kenya, 18 to 35 years of age, were enrolled. Every 2 months, cervical samples were collected for MG, Chlamydia trachomatis (CT), and Neisseria gonorrhoeae (GC) testing by polymerase chain reaction.
At enrollment, 16% were infected with MG. Seventy-seven subjects acquired 107 MG infections, giving an incidence of 22.7 per 100 women-years. Incident CT (adjusted hazard ratio [HR] = 2.4; 95% confidence interval [CI] = 1.5-4.0), GC (HR = 2.0; 95% CI = 1.2-3.5), and HIV infection (adjusted HR = 2.2; 95% CI = 1.3-3.7) were associated with an increased risk of MG. Seventeen percent, 9%, and 21% of MG infections persisted 3, 5, and >or=7 months, respectively.
The high incidence of MG, greater than that for both CT (14.0%) and GC (8%), association with common sexually transmitted infection risk factors, and persistence in the female genital tract supports its role as a common sexually transmitted infection in Kenyan women.
本研究的目的是评估肯尼亚一个高暴露女性群体中生殖支原体（MG）的危险因素及持续存在情况。
招募了肯尼亚内罗毕258名年龄在18至35岁的性工作者。每2个月采集宫颈样本，通过聚合酶链反应检测MG、沙眼衣原体（CT）和淋病奈瑟菌（GC）。
入组时，16%的人感染了MG。77名受试者发生了107次MG感染，发病率为每100妇女年22.7例。新发CT感染（校正风险比[HR]=2.4；95%置信区间[CI]=1.5 - 4.0）、GC感染（HR = 2.0；95% CI = 1.2 - 3.5）和HIV感染（校正HR = 2.2；95% CI = 1.3 - 3.7）与MG感染风险增加相关。分别有17%、9%和21%的MG感染持续3、5和≥7个月。
MG的高发病率高于CT（14.0%）和GC（8%），与常见性传播感染危险因素相关，且在女性生殖道持续存在，这支持了其作为肯尼亚女性常见性传播感染的作用。
